Porous selenium nanozymes targeted scavenging ROS synchronize therapy local inflammation and sepsis injury

References

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1063Porous selenium nanozymes targeted scavenging ROS synchronize therapy local inflammation and sepsis injuryhttps://doi.org/10.1016/j.apmt.2020.100929Othersa novel mesoporous selenium-hyaluronic acid nanoenzyme therapeutic system (MSe-HA NPs)

Materials

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1063MSe NPs17.7nmOthersThen, the N2 adsorption and desorption isotherms showed that MSe NPs has obvious hysteresis loop (Fig. 1E) with an average pore size of 17.7 nm (Fig. 1F), indicating that MSe NPs were typical mesoporous nanoparticles [42,47], whereas the solid Se NPs without corresponding performance (Fig. 1G).
1063Se NPs546.470
1063MSe NPs150nmTEMThe transmission electron microscope (TEM) (Fig. 1A) and high-resolution TEM (HRTEM) (Fig. S1B) showed that the mesochannels distributed on the spheres throughout the MSe NPs with average size of 150 nm, which proved we have prepared the porous Se NPs.1160.195

Kinetics

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1063MSe-HA NPsGPxGSH159.8μM26.81μM/min10631063
1063Se NPsGPxGSH200.59μM13.51μM/min10631063
1063MSe NPsGPxGSH157.72μM27.36μM/min10631063

Applications

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1063MSe NPssynchronize therapy local inflammation and sepsis injury