Electrochemical biosensor for ultrasensitive exosomal miRNA analysis by cascade primer exchange reaction and MOF@ Pt@ MOF nanozyme

References

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522Electrochemical biosensor for ultrasensitive exosomal miRNA analysis by cascade primer exchange reaction and MOF@ Pt@ MOF nanozymehttps://doi.org/10.1016/j.bios.2020.112554Compositethe nanozyme could act as a signal probe (MIL-88@Pt@MIL-88@sDNA)

Materials

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BET
b nanozyme
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522MIL-88@Pt@MIL-88@sDNA250nmTEMAfter growing MIL-88 shell, the Pt NPs anchored at the MOF core seem to be covered and the size of obtained composites increase to about 250 nm (Fig. 1E and F),76.9640 m2 g−1 and 0.2606 cm3 g−1
522MIL-88@Pt@MIL-88@sDNA40-60nmSEMThe size distribution of CeO2 NPs ranged from 40 to 60 nm, which corresponds well with the results expected from a synthesis using with ZIF-8 NPs.

Kinetics

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522MIL-88@Pt@MIL-88@sDNATMB522522

Applications

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linear range
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522MIL-88@Pt@MIL-88@sDNAexosomal miRNAs detectionexosomal miRNAsE-chem1 fM to 1 nM2.00fM