Graphdiyne-templated palladium-nanoparticle assembly as a robust oxygen generator to attenuate tumor hypoxia

References

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321Graphdiyne-templated palladium-nanoparticle assembly as a robust oxygen generator to attenuate tumor hypoxiahttps://doi.org/10.1016/j.nantod.2020.100907CompositeHere, we described a strategy to prepare a stable nanocatalyst that two-dimensional (2D) graphdiyne (GDY) serves as a template to immobilize catalytic palladium nanoparticles (PdNPs) on the GDY surface. In the presence of H2O2, the PdNPs/GDY composite functions as an oxygen generator to decompose H2O2 to produce molecular oxygen, which efficiently attenuates tumor hypoxia and delays tumor growth

Materials

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321PdNPs/GDY3.1nmTEMIn contrast, many Pd nanoparticles, with an average size of 3.1 nm, were observed and uniformly distributed on the GDY sheet after reduction with NaBH4 (Fig. 1c and d, Fig. S2), demonstrating the successful preparation of the PdNPs/GDY composite.

Kinetics

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321PdNPs/GDYCATH2O259mM342.9μM/s321321

Applications

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321PdNPs/GDYOur findings demonstrate that the rational design of a nano