Zinc oxide particles catalytically generate nitric oxide from endogenous and exogenous prodrugs

References

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375Zinc oxide particles catalytically generate nitric oxide from endogenous and exogenous prodrugshttps://doi.org/10.1002/smll.201906744Metal oxideZinc oxide (ZnO) particles

Materials

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375ZnO10.11.8μmSEMThe average size of the bowtie was 10.1 ± 1.8 μm (length) and 2.6 ± 0.9 μm (width, defined as the distance of the two outmost branches at the edge) (Fig. 1ai and aii).

Kinetics

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Applications

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375ZnONO-releasing biomaterials and devicesNOE-chem1 × 10−9M
375ZnONO-releasing biomaterials and devicesNOE-chem1 × 10−9MIn detail, the probe was suspended in a glass vial filled with 10 mL 0.1 M H2SO4/0.1 M KI solution. Incremental volumes of 25 × 10−6 m KNO2 solution were added to the glass vial after a stable current baseline was observed. NO concentration was determined based on the amount of KNO2 added as the conversion of KNO2 to NO was stoichiometrically 1:1. To assess the capability of ZnO particles to catalyze GSNO to generate NO, the NO probe was placed in a glass vial containing 3.95 mL ZnO particles (0.1–0.4 g L−1) in PBS. Fifty microliters of GSNO solutions (5× 10−6–100 × 10−6 m) was added to the glass vial when a stable baseline was reached. Changes in current response were recorded over time using LabScribe2 software. All NO measurements were carried out in dark at 37 °C on a hot plate with constant stirring.