Glycoengineering Artificial Receptors for Microglia to Phagocytose Aβ aggregates

References

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1182Glycoengineering Artificial Receptors for Microglia to Phagocytose Aβ aggregateshttps://doi.org/10.1039/D0SC07067JMOFn-porphyrin metal–organic frameworks (Mn-MOFs) with superoxide dismutase (SOD) and catalase (CAT) mimic activity are employed to carry N-azidoacetylmannosamine (AcManNAz) , AcManNAz@Mn-MOFs (Az@MOF)

Materials

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BET
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1182Az@MOFScanning electron microscopy (SEM) imaging indicated the extremely homogeneous morphology with a length of 200 nm and a width of 75 nm (Fig. 1a). Furthermore, transmission electron microscopy (TEM) images of Mn-MOFs in Fig. 1b directly displayed a pore size of 1.25 nm, which is in accordance with the result of N2 adsorption–desorption (1.25 nm) in Fig. S7.† The pore size of 1.25 nm permitted the encapsulation and release of AcManNAz (MW = 430).

Kinetics

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Applications

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1182Az@MOFeradicate over-expressed reactive oxygen species, synergistically promote the phagocytosis and clearance of Aβ with significantly enhanced activity and negligible adverse effects