Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H2O2 Generation

References

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title
DOI
material type
comment
710Nanozyme-Augmented Tumor Catalytic Therapy by Self-Supplied H2O2 Generationhttps://doi.org/10.1021/acsabm.0c00056CompositeHerein, we fabricated a nanozyme platform (Fe@Fe3O4@Cu2-xS, named as MNPs) possessing peroxidase enzyme-like activity, and then introduced β-Lapachone (La) to assemble an effective nanozyme (LaMNPs) to boost the production of reactive oxygen species and upregulate the level of H2O2 by the released La in an acidic tumor microenvironment

Materials

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material
size
size err
size unit
size type
size comment
BET
b nanozyme
b 10n
b unit
specific act
sa 10n
sa unit
comment
710LaMNPs-PEG71nmDLSThe HD and potential of LaMNPs-PEG were about ~71 nm and ~-27.3 mV by dynamic light scattering (DLS)

Kinetics

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material
enzyme type
substrate
pH
T
km
km err
km 10n
km unit
vmax
vmax err
vmax 10n
vmax unit
kcat
kcat err
kcat 10n
kcat unit
kcat/km
kcat/km 10n
kcat/km unit
comment
710MNPs-PEGPODTMB0.18mM54-8M/s710
710MNPs-PEGPODH2O20.17mM42-8M/s710

Applications

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material
application
target
method
linear range
linear ran unit
LOD
lod unit
recovery
comment
710LaMNPsinhibition of the tumor growth