Self‐Assembled Single‐Site Nanozyme for Tumor‐Specific Amplified Cascade Enzymatic Therapy

References

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ref
title
DOI
material type
comment
501Self‐Assembled Single‐Site Nanozyme for Tumor‐Specific Amplified Cascade Enzymatic Therapyhttps://doi.org/10.1002/anie.202008868Compositecopper hexacyanoferrate (Cu-HCF) modified with polyethylene glycol (PEG) protection layer single-site nanozymes(Cu-HCF SSNEs)

Materials

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ref
material
size
size err
size unit
size type
size comment
BET
b nanozyme
b 10n
b unit
specific act
sa 10n
sa unit
comment
501Cu-HCF SSNEs128.34.2nmDLSThe hydrodynamic size of SSNEs was measured to be 128.3±4.2 nm by dynamic light scattering (DLS) analysis, which is larger than the TEM results due to the existence of PEG layer.
501Cu-HCF SSNEs102.521.8nmTEMMonodispersed SSNEs were obtained with a statistical size of 102.5±21.8 nm

Kinetics

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ref
material
enzyme type
substrate
pH
T
km
km err
km 10n
km unit
vmax
vmax err
vmax 10n
vmax unit
kcat
kcat err
kcat 10n
kcat unit
kcat/km
kcat/km 10n
kcat/km unit
comment
501Cu-HCF SSNEsOXDGSH0.090.05mM25.70.8-3mM/s501501
501Cu-HCF SSNEsOXDH2O271.98.2mM17.20.5-3mM/s501SSNEs pretreated with GSH (denoted as SSNEs-G)

Applications

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ref
material
application
target
method
linear range
linear ran unit
LOD
lod unit
recovery
comment
501Cu-HCF SSNEsTumor-Specific Amplified Cascade Enzymatic Therapy