Biomimetic Design of Mitochondria‐Targeted Hybrid Nanozymes as Superoxide Scavengers

References

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DOI
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1062Biomimetic Design of Mitochondria‐Targeted Hybrid Nanozymes as Superoxide Scavengershttps://doi.org/10.1002/adma.202006570CompositeFenozymes

Materials

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BET
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1062MnO2 FenozymesTEMTransmission electron microscopy (TEM) revealed the uniform diameter of the hollow structure of FTn was ≈12 nm after protein negative staining (Figure 1b). The diameter of FTn inner cavity is 8 nm, and the incorporated MnO2 nanozymes within the FTn core (MnO2 Fenozymes) were observed by TEM. The MnO2 Fenozymes showed monodispersed spherical morphology (Figure 1c) with mean diameters of ≈6.5 nm, which did not change after TPP conjugation (Figure 1d).

Kinetics

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1062MnO2 FenozymePODTMB6.36mM2.74nM/s15.42-31/s1062M-1 s-11062
1062MnO2 FenozymeCATH2O211.43mM489.60nM/s2.211/s10623M-1 s-11062
1062Fe3 O4 FenozymeCATH2O213.21mM548.70nM/s2.4711/s10623M-1 s-11062
1062Fe3 O4 FenozymePODTMB7.08mM28.08nM/s157.95-31/s1062M-1 s-11062

Applications

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1062FenozymesSuperoxide Scavengers