A Phosphatase‐Mimetic Nano‐Stabilizer of Mast Cells for Long‐Term Prevention of Allergic Disease

References

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title
DOI
material type
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779A Phosphatase‐Mimetic Nano‐Stabilizer of Mast Cells for Long‐Term Prevention of Allergic Diseasehttps://doi.org/10.1002/advs.202004115Metal oxideceria nanoparticle (CeNP-) based phosphatase-mimetic nano-stabilizers (PMNSs)

Materials

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material
size
size err
size unit
size type
size comment
BET
b nanozyme
b 10n
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specific act
sa 10n
sa unit
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779PMNSs9nmDLSacquiring water-dispersible and stable PMNSs (with a hydrodynamic diameter of ≈9 nm) for further biomedical applications

Kinetics

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substrate
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T
km
km err
km 10n
km unit
vmax
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vmax 10n
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kcat
kcat err
kcat 10n
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kcat/km
kcat/km 10n
kcat/km unit
comment
779PMNSshydrolaseO-phospho-L-tyrosine (P-Tyr)4.23-6M1.92-9M/s779The phosphatase-mimetic activity of PMNSs at different Ce concentrations (5,10, 20, and 40 μg/mL) or different P-Tyr concentrations (9, 18, 36, and 72 μM) was detected by the malachite green assay (Sangon Biotech Co., Ltd., China). Theabsorbance of the malachite green solution containing P-Tyr was used as blank. A phosphate standard curve was obtainedby using KH2PO4as the substrate

Applications

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target
method
linear range
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LOD
lod unit
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779PMNSsPrevention of Allergic Disease