An Activatable Nanoenzyme Reactor for Coenhanced Chemodynamic and Starving Therapy Against Tumor Hypoxia and Antioxidant Defense System

References

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title
DOI
material type
comment
863An Activatable Nanoenzyme Reactor for Coenhanced Chemodynamic and Starving Therapy Against Tumor Hypoxia and Antioxidant Defense Systemhttps://doi.org/10.31635/ccschem.020.202000259Compositeactivatable nanoenzyme reactor(NER):Fluorescent reporters (FRs) and bioenzyme glucose oxidase (GOX) were coassembled on nanozyme manganese dioxide nanosheets(MDN), which was enwrapped by the tumor-targeting material, hyaluronic acid (HA).

Materials

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material
size
size err
size unit
size type
size comment
BET
b nanozyme
b 10n
b unit
specific act
sa 10n
sa unit
comment
863NER125nmDLSIts size and zeta potential were about 125 nm ( Supporting Information Figure S2, black curve) and −27.9 mV (Figure 1d, black curve), as measured by DLS.

Kinetics

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material
enzyme type
substrate
pH
T
km
km err
km 10n
km unit
vmax
vmax err
vmax 10n
vmax unit
kcat
kcat err
kcat 10n
kcat unit
kcat/km
kcat/km 10n
kcat/km unit
comment
863NERCATH2O2863

Applications

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material
application
target
method
linear range
linear ran unit
LOD
lod unit
recovery
comment
863NERCoenhanced chemodynamic and starving therapy against tumor hypoxia and antioxidant defense system