An Ultrasmall RuO2 Nanozyme Exhibiting Multienzyme-like Activity for the Prevention of Acute Kidney Injury

References

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868An Ultrasmall RuO2 Nanozyme Exhibiting Multienzyme-like Activity for the Prevention of Acute Kidney Injuryhttps://doi.org/10.1021/acsami.0c07886Metal oxidethe ultrasmall RuO2NPs promising as a nanozyme for the prevention of AKI

Materials

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BET
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868RuO22nmTEMthe mean diameter of the RuO2NPs was ∼2 nm, and the hydrodynamic size of RuO2NPs was about 5.4 nm

Kinetics

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868RuO2CATH2O23.59mM2.29mM/min868

Applications

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868RuO2The NP catalytic properties mimic the activity of catalase, peroxidase, superoxide dismutase, and glutathione peroxidase. The nanozyme can be efficiently and rapidly absorbed by human embryonic kidney cells while significantly reducing ROS-induced apoptosis by eliminating excess ROS. After intravenous injection, the ultrasmall RuO2NPs significantly inhibit the development of AKI in mice. In vivo toxicity experiments demonstrate the biosafety of the NPs after long-term preventing.ROS