Isolation and Detection of Exosomes Using Fe2O3 Nanoparticles

References

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title
DOI
material type
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1145Isolation and Detection of Exosomes Using Fe2O3 Nanoparticleshttps://doi.org/10.1021/acsanm.0c02807Metal oxidecarboxyl group-functionalized iron oxide nanoparticles (C-IONPs)

Materials

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size
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BET
b nanozyme
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1145C-IONPs250nmTEMOn the other hand, DLS analysis also revealed uniform hydrodynamic size distribution of the nanoparticles. The hydrodynamic radius of the C-IONPs was found to be 318.4 ± 13.58 nm with a polydispersity of 41.25% ± 6.86 (Figure S4).

Kinetics

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substrate
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T
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vmax
vmax err
vmax 10n
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kcat
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1145C-IONPsPODTMB0.0992mM0.156-8M/s1.04 × 10–41145
1145C-IONPsPODH2O2114mM0.197-8M/s1.31 × 10–41145

Applications

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method
linear range
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LOD
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1145C-IONPsexhibits an excellent specificity for OVCAR3 cell-derived exosomesexosomeE-chem6.25 × 10^5-1.0 × 10^7exosomes/mL1.25 × 10^6exosomes/mL