In Situ Fabrication of Ultrasmall Gold Nanoparticles/2D MOFs Hybrid as Nanozyme for Antibacterial Therapy

References

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167In Situ Fabrication of Ultrasmall Gold Nanoparticles/2D MOFs Hybrid as Nanozyme for Antibacterial Therapyhttps://doi.org/10.1002/smll.202000553Compositeultrasmall Au nanoparticles (UsAuNPs) are grown on ultrathin 2D metal–organic frameworks (MOFs) via in situ reduction

Materials

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167UsAuNPs/MOFs150nmTEMThe UsAuNPs/MOFs present uniform dispersion with an average size of around 150 nm (Figure S11, Supporting Information).

Kinetics

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167UsAuNPs/MOFs HybridPODTMB5.0300.101mM167167
167UsAuNPs/MOFs HybridPODH2O25.0307.94mM167

Applications

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167UsAuNPs/MOFsH2O2 is widely used in the treatment of bacterial infections. However, compared with H2O2, hydroxyl radicals are much more reactive and can cause more serious oxidative damages to bacteria.[37] Given the excellent POD-like activity of the prepared UsAuNPs/MOFs, the in vitro antimicrobial activities against Staphylococcus aureus and Escherichia coli were evaluated in the presence of H2O2.