Colorimetric determination of tumor cells via peroxidase-like activity of a cell internalizable nanozyme: Hyaluronic acid attached-silica microspheres containing accessible magnetite nanoparticles

References

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444Colorimetric determination of tumor cells via peroxidase-like activity of a cell internalizable nanozyme: Hyaluronic acid attached-silica microspheres containing accessible magnetite nanoparticleshttps://doi.org/10.1016/j.colsurfa.2020.124812CompositeHA attached form of Fe3O4@SiO2 microspheres (HA@Fe3O4@SiO2 microspheres)

Materials

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BET
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444HA@Fe3O4@SiO26.24μmSEM
444Fe3O4@SiO26.25μmSEM

Kinetics

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Applications

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444HA@Fe3O4@SiO2Colorimetric determination of tumor cellstumor cellColorIn the presence of HeLa cells, the visible region absorbance sharply decreased up to the cell concentration of 0.25 × 106 cells/mL, with both nanozymes (Fig. 9A). In the concentration range of 0.25–4.0 × 106 cells/mL, the visible region absorbance linearly decreased with the increasing cell concentration, with satisfactorily high correlation coefficients for both nanozymes. However, a sharper linear decrease with almost 1.6 times higher slope was observed with HA@Fe3O4@SiO2 microspheres with respect to Fe3O4@SiO2 microspheres with HeLa cells.
444HA@Fe3O4@SiO2Colorimetric determination of tumor cellstumor cellColor