A Nanomedicine Fabricated from Gold Nanoparticles‐Decorated Metal–Organic Framework for Cascade Chemo/Chemodynamic Cancer Therapy

References

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440A Nanomedicine Fabricated from Gold Nanoparticles‐Decorated Metal–Organic Framework for Cascade Chemo/Chemodynamic Cancer Therapyhttps://doi.org/10.1002/advs.202001060Compositemetal–organic framework (MOF) nanoparticles and gold nanoparticles (Au NPs)(PEG-Au/FeMOF@CPT NPs)

Materials

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440PEG-Au/FeMOF@CPT NPs50nmTEMMonodispersed nanoparticles with the diameter around 50 nm were observed in transmission electron microscopy (TEM) image (Figure 1a and Figure S1, Supporting Information). Au/FeMOF NPs were further fabricated using FeMOF NPs as platforms by directly reducing HAuCl4 in water using sodium borohydride as a reductant. As shown in Figure 1b,d, dark spots corresponding to the Au NPs ≈5 nm in diameter were observed on the exterior surface of Au/FeMOF NPs.1451

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Applications

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440PEG-Au/FeMOF@CPT NPsCancer Therapy
440PEG-Au/FeMOF@CPT NPsCancer TherapyTriggered by the high concentration of phosphate inside the cancer cells, Au/FeMOF@CPT NPs effectively collapse after internalization, resulting in the complete drug release and activation of the cascade catalytic reactions.