Iridium/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer

References

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174Iridium/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancerhttps://doi.org/10.1016/j.biomaterials.2020.119848CompositeIrRu-GOx@PEG NPs

Materials

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BET
b nanozyme
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174IrRu-GOx@PEG NPs43nmTEMTherefore, we synthesized IrRu NPs with different ratio of Ir and Ru elements to obtain better enzyme-like catalytic activity. the TEM image showed Ir2Ru1 NPs, Ir4Ru1 NPs, and Ir8Ru1 NPs are uniformly dispersed black particles with an average particle size of ~2 nm (Fig. 1A and B) and ~3 nm (Figs. S1A and B), ~4 nm.As shown in TEM images, the IrRuGOx@PEG NPs obtained by PEG-coated IrRu NPs were spherical and the average particle size was ~43 nm

Kinetics

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174IrRu-GOx@PEG NPsPODH2O26.020.01mM2.12-8M/s174
174IrRu-GOx@PEG NPsPODTMB6.00.351mM174

Applications

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174IrRu-GOx@PEG NPsIridium/ruthenium nanozyme reactors with cascade catalytic ability for synergistic oxidation therapy and starvation therapy in the treatment of breast cancer