Tumor Microenvironment-Activatable Cyclic Cascade Reaction to Reinforce Multimodal Combination Therapy by Destroying the Extracellular Matrix

References

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1021Tumor Microenvironment-Activatable Cyclic Cascade Reaction to Reinforce Multimodal Combination Therapy by Destroying the Extracellular Matrixhttps://doi.org/10.1021/acsami.1c02011Compositean intelligent BPNs-Arg-GOx@MnO2 (BAGM) nanozyme is innovatively designed as a multimodal synergistic therapeutic paradigm that possesses both nitric oxide (NO) self-supplying and ECM degradation properties to reinforce the therapy effect by a tumor microenvironment (TME)- activatable cyclic cascade catalytic

Materials

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Kinetics

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1021BPNs-Arg-GOx@MnO2 (BAGM)1021

Applications

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1021BPNs-Arg-GOx@MnO2 (BAGM)In summary, we have successfully structured a TME-activatable BAGM nanozyme for an MR/US imaging-guided multimodal synergistic therapy nanoplatform with PTT/starvation therapy/NO gas therapy