Investigation of efficient synergistic and protective effects of chitosan on copper nanoclusters: Construction of highly active and stable nanozyme for colorimetric and fluorometric dual-signal biosensing

References

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999Investigation of efficient synergistic and protective effects of chitosan on copper nanoclusters: Construction of highly active and stable nanozyme for colorimetric and fluorometric dual-signal biosensinghttps://doi.org/10.1016/j.snb.2021.129522CompositeCopper nanoclusters (CuNCs) have advantages of low cost, excellent biocompatibility, and good fluorescence properties, but they are seldom used as nanozymes for biosensing owing to their low catalytic activity and poor stability. Herein, a natural polymer, chitosan (CS), was explored to effectively promote the peroxidase-like property of glutathione-protected copper nanoclusters (GSH-CuNCs).

Materials

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b nanozyme
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sa 10n
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Kinetics

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999CS@GSH-CuNCsPODH2O227.3mM2.53-7M/s999
999CS@GSH-CuNCsPODABTS1.67mM4.85-7M/s999

Applications

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999CS@GSH-CuNCsFluor5-100mU/mL1.4mU/mL
999CS@GSH-CuNCsdetection of AChE activity.Color10-120mU/mL3.3mU/mL
999CS@GSH-CuNCsdetection of cholineFluor5-100μM1.2μM
999CS@GSH-CuNCsdetection of cholineColor20-150μM6.5μM