Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy

References

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596Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapyhttps://doi.org/10.1039/D0TB00357CCompositean efficient ROS generator (GOx@Pd@ZIF-8). Glucose oxidase (GOx) and palladium (Pd) cube nanozymes were incorporated in zeolitic imidazolate framework-8 (ZIF-8) by biomimetic mineralization.

Materials

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BET
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596GOx@Pd@ZIF-8SEMThe average particle size was ca. 130 nm as obtained from SEM measurements, while the value was measured to be 480 nm using the DLS method (Fig. S2, ESI†).

Kinetics

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596GOx@Pd@ZIF-8OXD596596

Applications

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596GOx@Pd@ZIF-8a synergistic cancer therapeutic that blocks glucose metabolism and produces ROS