Intracellular Activation of Anticancer Therapeutics Using Polymeric Bioorthogonal Nanocatalysts

References

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1066Intracellular Activation of Anticancer Therapeutics Using Polymeric Bioorthogonal Nanocatalystshttps://doi.org/10.1002/adhm.202001627Compositea ruthenium-based “polyzyme” employing a poly(oxanorbornene imide) scaffold

Materials

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1066polyzymes80nmDLSTransmission electron microscopy (TEM, Figure S7, Supporting Information) indicated a diameter of ≈30 nm (dry). Dynamic light scattering (DLS, Figure S7, Supporting Information) showed that the size of the self-assemblies was ≈80 nm in solution, indicating some degree of swelling of self-assembled NP in aqueous media.
1066polyzymes30nmTEMTransmission electron microscopy (TEM, Figure S7, Supporting Information) indicated a diameter of ≈30 nm (dry). Dynamic light scattering (DLS, Figure S7, Supporting Information) showed that the size of the self-assemblies was ≈80 nm in solution, indicating some degree of swelling of self-assembled NP in aqueous media.

Kinetics

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Applications

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1066polyzymesIntracellular Activation of Anticancer Therapeutics