Pharmacologic Vitamin C-Based Cell Therapy via Iron Oxide Nanoparticle-Induced Intracellular Fenton Reaction

References

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title
DOI
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585Pharmacologic Vitamin C-Based Cell Therapy via Iron Oxide Nanoparticle-Induced Intracellular Fenton Reactionhttps://doi.org/10.1021/acsanm.9b02405CompositePolyaspartic-Acid-Coated and Vitamin C-Bound Iron Oxide Nanoparticle (Fe3O4-PAA-PB-AA)

Materials

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BET
b nanozyme
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585Fe3O4-PAA-PB-AA8−10nmTEMTEM image of hydrophobic Fe3O4 nanoparticle shows the particle size of 8−10 nm. SEM image of Fe3O4-PAA-PB-AA/PAA-PB-AA/Fe3O4-PA shows the size in the range of 20−70 nm which also corroborate with dynamic light scattering based hydrodynamic size (Figure 1).

Kinetics

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kcat/km 10n
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Applications

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linear range
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585Fe3O4-PAA-PB-AAFenton/ferroptosis therapROS