Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors

References

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619Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumorshttps://doi.org/10.1016/j.biomaterials.2020.120537Compositeintegrating DOX with the Fe(VI)-nanoplatform, followed by incorporation of n-heneicosane (HE) and polyethylene glycol (PEG) chains (designated as DOX-Fe(VI)@HMS-HE-PEG, abbreviated as DFHHP)

Materials

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BET
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619DFHHPThe constructed HMS was ca. 100 nm in diameter (Fig. 1A and B). The average hydrodynamic particle diameters of HMS and DFHHP were ca. 150 nm with a narrow size distribution (Fig. 1E), indicating good dispersion of these nanomaterials in aqueous media.

Kinetics

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619DFHHPCATH2O2619619

Applications

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619DFHHPovercoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors