Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions

References

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title
DOI
material type
comment
1155Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutionshttps://doi.org/10.1038/s41467-020-20275-0Multi-metalAu25, Au24Cu1 and Au24Cd1

Materials

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material
size
size err
size unit
size type
size comment
BET
b nanozyme
b 10n
b unit
specific act
sa 10n
sa unit
comment
1155Au252nmDLSThe hydrodynamic size of Au25 is determined to be 2.0 nm by dynamic light scattering (DLS), and the zeta potentials of all clusterzymes are around −35 mV, suggesting the ultrasmall size and good colloid stability (Supplementary Fig. 1).

Kinetics

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material
enzyme type
substrate
pH
T
km
km err
km 10n
km unit
vmax
vmax err
vmax 10n
vmax unit
kcat
kcat err
kcat 10n
kcat unit
kcat/km
kcat/km 10n
kcat/km unit
comment
1155Au24Cu1CAT0.35mM/min1155
1155Au25CAT0.074mM/min1155
1155Au24Cd1GPx0.10mM/min1155
1155Au24Cu1GPx0.34mM/min1155
1155Au25GPx0.47mM/min1155

Applications

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material
application
target
method
linear range
linear ran unit
LOD
lod unit
recovery
comment
1155Au25, Au24Cu1 and Au24Cd1modulation of neuroinflammation