The Fe‐N‐C Nanozyme with Both Accelerated and Inhibited Biocatalytic Activities Capable of Accessing Drug–Drug Interactions

References

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160The Fe‐N‐C Nanozyme with Both Accelerated and Inhibited Biocatalytic Activities Capable of Accessing Drug–Drug Interactionshttps://doi.org/10.1002/ange.202003949Single-atomFe-N-C

Materials

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BET
b nanozyme
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160Fe-N-CThetransmission electron microscopy (TEM) images disclosed the onion-like nanoparticles of tens of nanometers with multiple graphitic shells and void cores for Fe-N-C-850

Kinetics

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160Fe-N-C-850OXDTMBRT0.23mM0.133μM/s160160
160Fe-N-C-400OXDTMBRT0.269mM0.338μM/s160160

Applications

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160Fe-N-CIt is interesting that Fe-N-C not only demonstrated the similar function of CYP3A4 in the metabolization of 1,4-DHP but also had avery high level of similarity in inhibiting interactions with other drugs