Fe3O4@ Pt nanozymes combining with CXCR4 antagonists to synergistically treat acute myeloid leukemia

References

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992Fe3O4@ Pt nanozymes combining with CXCR4 antagonists to synergistically treat acute myeloid leukemiahttps://doi.org/10.1016/j.nantod.2021.101106CompositeTo overcome these problems, a multifunctional nanoplatform of Fe3O4@Pt composite nanozyme conjugating CXCR4 antagonist was designed, aiming to synergistically treat AML for the first time, in which, the CXCR4 antagonist was used to specifically target AML cells as well as to significantly interfere CXCR4/CXCL12 axis. In the mildly acidic lysosome microenvironment, highly toxic reactive oxygen species (ROS) was generated through the sequential catalytic reactions of Fe3O4@Pt to trigger AML cells apoptosis, leaving the normal cells unharmed.

Materials

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BET
b nanozyme
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sa 10n
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Kinetics

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992Fe3O4@PEGPODH2O22-1120-8022.59mM0.028-6M/s992
992Fe3O4@PEGPODH2O213.768mM29.06-8M/s992

Applications

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992Fe3O4@Pt@E5AML treatment