Targeted self-activating Au-Fe3O4 composite nanocatalyst for enhanced precise hepatocellular carcinoma therapy via dual nanozyme-catalyzed cascade reactions

References

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806Targeted self-activating Au-Fe3O4 composite nanocatalyst for enhanced precise hepatocellular carcinoma therapy via dual nanozyme-catalyzed cascade reactionshttps://doi.org/10.1016/j.apmt.2020.100827CompositeBriefly, the composite nanozyme CD44MMSN/AuNPs were assembled with two self-activable nanocatalysts including the inner core peroxidase-mimic Fe3O4 magnetic nanoparticles (MNPs), and the outer glucose oxidase-mimic AuNPs situated within large aperture mesoporous silicon (MMSN/AuNPs), and then functionalized with cell ligand hyaluronic acid (HA)

Materials

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BET
b nanozyme
b 10n
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sa 10n
sa unit
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806CD44MMSN/AuNPs417.39

Kinetics

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kcat 10n
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kcat/km
kcat/km 10n
kcat/km unit
comment
806CD44MMSN/AuNPsPODTMB15.37mM9.06-8M/s806
806CD44MMSN/AuNPsPODH2O26.35mM3.85-8M/s806

Applications

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806CD44MMSN/AuNPsenhanced precise hepatocellular carcinoma therapy