A cerium oxide@ metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy

References

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1179A cerium oxide@ metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapyhttps://doi.org/10.1039/D1CC00001BMOFA Material of Institute Lavoisie-NH2 (MIL) shell was used to protect the enzymatic activity of CeOxvia surface modification to form a core–shell MOF nanohybrid (CeOx@MIL) with abundant –NH2 groups as postsynthetic modification sites.The target moiety poly (ethylene glycol)-folate (PEG-FA) and the signal element cyanine 3 (Cy3)-labelled caspase-3 substrate peptide (Cy3-p) were assembled on the surface of CeOx@MIL via the amide reaction to obtain functionalized CeOx@MIL (CeOx@fMIL).

Materials

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BET
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1179CeOx@fMIL112nmDLSAfter coating with MIL, the dynamic light scattering (DLS) of CeOx indicated an increase in the mean hydrodynamic diameter particle size from 17 to 112 nm.

Kinetics

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Applications

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1179CeOx@fMILas a tandem catalyst for enhanced photodynamic therapy