Enhancing Enzyme-like Activities of Prussian Blue Analog Nanocages by Molybdenum Doping: Toward Cytoprotecting and Online Optical Hydrogen Sulfide Monitoring

References

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456Enhancing Enzyme-like Activities of Prussian Blue Analog Nanocages by Molybdenum Doping: Toward Cytoprotecting and Online Optical Hydrogen Sulfide Monitoringhttps://doi.org/10.1021/acs.analchem.0c01028CompositeMolybdenum-polysulfide-deposited nickel–iron bimetal Prussian-blue-analog-based hollow nanocages (Nanocages)

Materials

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BET
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456PBAs60nmTEMThe size of the PBAs was accurately controlled to be ∼60 nm with smooth surfaces through a 40 °C water-bath-assisted synthesis (Figure S1A,B, Supporting Information). The elements Ni and Fe existed in the PBA in the energy-dispersive X-ray spectroscopy (EDS) spectrum (Figure S1C) and in the elemental mapping images (Figure S1D), which indicated that the bimetal nanocubes were well synthesized. From the TEM images of the Nanocages (Figure 1A), a cubic morphology with an average size of 60 nm was retained, but the cube became hollow and the surfaces became much rougher.60.11

Kinetics

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456NanocagesOXDDopamine9.82μM3.67-8M/s456

Applications

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456NanocagesThe peroxidase- and catalase-mimicking activities were applied to eliminate reactive oxygen species in cells
456Nanocagesthe laccase-like activity of Nanocages was integrated with an online sensing platform for in vivo and continuous optical hydrogen sulfide monitoring in the brains of living ratshydrogen sulfideE-chem0.1-15μM33nM
456Nanocagesthe laccase-like activity of Nanocages was integrated with an online sensing platform for in vivo and continuous optical hydrogen sulfide monitoring in the brains of living ratshydrogen sulfideE-chem0.1-15μM33nMAfter testing the excellent capabilities of the OODP toward H2S monitoring, the animal model was carried out to test the ability of the constructed method.