Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma

References

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1210Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain traumahttps://doi.org/10.7150/thno.51912Multi-metalwe developed a catalytic patch based on redox Cr-doped CeO2 (Cr/CeO2) nanozyme for noninvasive TBI treatment

Materials

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BET
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1210Cr/CeO28~12nmTEMthe transmission electron microscopy (TEM) and high-resolution TEM (HRTEM) images of Cr/CeO2 nanozyme in Figure S1 and 1G reveal that the size of nanozyme is about 8~12 nm, and interplanar spacing of the (111) plane of CeO2 is slightly reduced from 0.3123 Å to ~0.3047 Å after Cr doping.

Kinetics

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1210Cr/CeO2PODH2O20.8670.073mM0.1590.024-6M/s1210
1210Cr/CeO2PODTMB0.080.009mM0.1380.027-6M/s1210

Applications

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1210Cr/CeO2Cr/CeO2 nanozyme can improve the survival rate of LPS induced neuron cells via decreasing excessive RONS. The in vivo experiments show the Cr/CeO2 nanozyme can promote wound healing and reduce neuroinflammation of mice following brain trauma. The catalytic patch based on nanozyme provides a noninvasive topical treatment route for TBI as well as other traumas diseases.