Nanozyme Database

A biomimetic nanozyme/camptothecin hybrid system for synergistically enhanced radiotherapy

References

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ref	title	DOI	material type	comment
348	A biomimetic nanozyme/camptothecin hybrid system for synergistically enhanced radiotherapy	https://doi.org/10.1039/D0TB00676A	Others	camptothecin (CPT)-loaded hollow MnO2 core and an external tumor cell membrane.Cancer cell membranes coated MC nanoparticles (CMC)

Materials

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ref	material	size	size err	size unit	size type	size comment	BET	b _nanozyme	b 10ⁿ	b unit	specific act	sa 10ⁿ	sa unit	comment
348	CMC	112.6	4.2	nm	TEM

Kinetics

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ref	material	enzyme type	substrate	pH	T	k_m	k_m err	k_m 10ⁿ	k_m unit	v_max	v_max err	v_max 10ⁿ	v_max unit	k_cat	k_cat err	k_cat 10ⁿ	k_cat unit	k_cat/k_m	k_cat/k_m 10ⁿ	k_cat/k_m unit	comment
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Applications

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ref	material	application	target	method	linear range	linear ran unit	LOD	lod unit	recovery	comment
348	CMC	The anti-tumor mechanism of this system includes two aspects: (i) the generated oxygen can improve the hypoxic state of the tumor microenvironment and enhance the radiotherapy sensitivity and (ii) CPT can induce cell cycle arrest in the S-phase at a low dose, which further increases the radio-sensitivity of tumor cells and augmented radiation-induced tumor damage.