A nanozyme‐based artificial peroxisome ameliorates hyperuricemia and ischemic stroke

References

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506A nanozyme‐based artificial peroxisome ameliorates hyperuricemia and ischemic strokehttps://doi.org/10.1002/adfm.202007130CarbonFeN-carbon hollow nano-structure

Materials

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size
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BET
b nanozyme
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506Fe–N4 pero-nanozysome120nmTEMthe pero-nanozysome had a spherical morphology with hollow structure, and the average diameter was about 120 nm with a shell about 4–6nm thickness0.027 ±0.002U/mgUOD
506Fe–N4 pero-nanozysome120nmTEMthe pero-nanozysome had a spherical morphology with hollow structure, and the average diameter was about 120 nm with a shell about 4–6nm thickness6.0 ±0.9U/mgPOD
506Fe–N4 pero-nanozysome120nmTEMthe pero-nanozysome had a spherical morphology with hollow structure, and the average diameter was about 120 nm with a shell about 4–6nm thickness1257.1 ±122.8U/mgSOD
506Fe–N4 pero-nanozysome120nmTEMthe pero-nanozysome had a spherical morphology with hollow structure, and the average diameter was about 120 nm with a shell about 4–6nm thicknessU/mg
506Fe–N4 pero-nanozysome120nmTEMthe pero-nanozysome had a spherical morphology with hollow structure, and the average diameter was about 120 nm with a shell about 4–6nm thickness41.7 ± 7.9U/mgCAT

Kinetics

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506Fe–N4 pero-nanozysome (单位无法填写)CATH2O27.0RT0.09M2.34506The KM value of pero-nanozysome was about four times lower than that of N-nanozyme (Table S3, Supporting Information),
506Fe–N4 pero-nanozysomeOXDTMB4.5370.55mM45.27nM/s506In addition, pero-nanozysome also possessed higher catalytic efficiency than that of N-nanozyme (Figure 3e and Table S6, Supporting Information).
506Fe–N4 pero-nanozysomePODTMB4.5370.18mM299.8nM/s506pero-nanozysome exhibited higher enzymatic activity as evaluated by the values for KM and Vmax (Table S5, Supporting Information).
506Fe–N4 pero-nanozysomePODH2O24.537175.5mM567.9nM/s506pero-nanozysome exhibited higher enzymatic activity as evaluated by the values for KM and Vmax (Table S5, Supporting Information).
506Fe–N4 pero-nanozysomecascade reactionUA8.02516.64μM1.36-3μM/min506506

Applications

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506Fe–N4 pero-nanozysomeHyperuricemia and Ischemic Stroke