Self-Protecting Biomimetic Nanozyme for Selective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer’s Disease Model

References

Loading, please wait
ref
title
DOI
material type
comment
1253Self-Protecting Biomimetic Nanozyme for Selective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer’s Disease Modelhttps://doi.org/10.1021/jacs.0c08395CompositeThe CuxO@EM-K is made of CuxO nanozyme wrapped by modified 3xTg-AD mouse erythrocyte membrane with Aβ-targeting peptide KLVFF.

Materials

Loading, please wait
ref
material
size
size err
size unit
size type
size comment
BET
b nanozyme
b 10n
b unit
specific act
sa 10n
sa unit
comment
1253CuxO@EM-K78.2-165.3nmTEMThe average hydrodynamic diameter of CuxO-K increased from 78.2 ± 1.5 to 165.3 ± 3.9 nm (Figure S12A) due to formation of protein coronas around CuxO-K.

Kinetics

Loading, please wait
ref
material
enzyme type
substrate
pH
T
km
km err
km 10n
km unit
vmax
vmax err
vmax 10n
vmax unit
kcat
kcat err
kcat 10n
kcat unit
kcat/km
kcat/km 10n
kcat/km unit
comment
1253CuxO@EM-K1253

Applications

Loading, please wait
ref
material
application
target
method
linear range
linear ran unit
LOD
lod unit
recovery
comment
1253CuxO@EM-KSelective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer’s Disease Model