Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy

References

Loading, please wait
ref
title
DOI
material type
comment
106Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapyhttps://doi.org/10.1002/adma.202003563CompositeTGF-β inhibitor (TI)-loaded PEGylated iron manganese silicate nanoparticles (IMSN) (named as IMSN-PEG-TI) are constructed to trigger the therapeutic modality.

Materials

Loading, please wait
ref
material
size
size err
size unit
size type
size comment
BET
b nanozyme
b 10n
b unit
specific act
sa 10n
sa unit
comment
106IMSN-PEG-TI100nmTEMThe typical transmission electron microscopy (TEM) and scanning electron microscopy (SEM) images indicated the as-prepared IMSN exhibited a uniform spherical morphology with an average diameter of about100 nm, and the surface of IMSN became rough (Figure 1b,c).

Kinetics

Loading, please wait
ref
material
enzyme type
substrate
pH
T
km
km err
km 10n
km unit
vmax
vmax err
vmax 10n
vmax unit
kcat
kcat err
kcat 10n
kcat unit
kcat/km
kcat/km 10n
kcat/km unit
comment
106IMSN-PEG-TIPODH2O249.8-3M5.283-8M/s106106

Applications

Loading, please wait
ref
material
application
target
method
linear range
linear ran unit
LOD
lod unit
recovery
comment
106IMSN-PEG-TIThe results show that IMSN nanozyme exhibits both intrinsic peroxidase-like and catalase-like activities under acidic TME, which can decompose H2O2 into hydroxyl radicals (•OH) and oxygen (O2), respectively