Reactive Oxygen Species-Induced Aggregation of Nanozymes for Neuron Injury.

References

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311Reactive Oxygen Species-Induced Aggregation of Nanozymes for Neuron Injury.https://doi.org/10.1021/acsami.9b17509OthersHerein, we developed an ultrasmall organic nanozyme that can induce significant aggregation under an ROS-rich environment, and it can be used as natural targeting nanozymes to injury sites of the brain trauma.

Materials

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311organic nanozymesTEMAs imaged with TEM, the freshly prepared nanozymes show uniform and small diameters of about 3 nm (Figure 2a), and upon exposure to the radicals, for example, H2O2 or •OH (Figure S6a), they aggregated gradually to about 300 nm because of multiple disulphide bridging between particles. Likewise, the AFM image demonstrates a uniform height of about 3 nm for the nanozyme (Figure 2b). Under H2O2 or •OH treatments (Figure S6b), the nanozyme sizes increase significantly in width with similar morphologies to those in TEM images, but their heights reached only about 10 nm, likely resulting from a collapse of soft-structured nanozyme aggregation.

Kinetics

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311organic nanozymesmulti-functionalitiesTMB/H2O2311311

Applications

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311organic nanozymesprevent oxidative damage for TBI therapy to reduce the ROS level in damaged brain tissues