Single-Atom Nanozymes Linked Immunosorbent Assay for Sensitive Detection of Aβ 1-40: A Biomarker of Alzheimer’s Disease

References

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DOI
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535Single-Atom Nanozymes Linked Immunosorbent Assay for Sensitive Detection of Aβ 1-40: A Biomarker of Alzheimer’s Diseasehttps://doi.org/10.34133/2020/4724505Single-atomFe-N-C single-atom nanozymes (Fe-Nx SANs)

Materials

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BET
b nanozyme
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535Fe-Nx SANs50nmTEMIn Scheme 1, the well-defined Fe-Nx SANs had a typical nanotube structure with a diameter of around 50 nm. Moreover, distorted graphite layers were found in Fe-Nx SANs (Figure 1(a)) by high-resolution TEM (HRTEM).648.16 m2/g65U/mg

Kinetics

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pH
T
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535Fe-Nx SANsPODH2O23.63717.12mM24.48μM/min3.3551/min5356M-1 s-1535
535Fe-Nx SANsPODTMB3.6370.3322mM51.4μM/min7.0451/min53521.19M-1 s-1535

Applications

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LOD
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535Fe-Nx SANsDetection of Aβ 1-40Aβ 1-40Color1-2000pg/mL0.88pg/mL