Trienzyme-like iron phosphates-based (FePOs) nanozyme for enhanced anti-tumor efficiency with minimal side effects

References

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881Trienzyme-like iron phosphates-based (FePOs) nanozyme for enhanced anti-tumor efficiency with minimal side effectshttps://doi.org/10.1016/j.cej.2020.125574MetalFePOs nanozyme was prepared via a simple hydrothermal method. In a typical process, H2NCONH2 (6.0 g) and sodium lauryl sulfate (SDS, 0.5 g) were dissolved in deionized water (84 mL) and then magnetically stirred for 10 min to obtain a homogeneous solution. Afterwards, Fe2(SO4)3 (0.2 g) and phosphoric acid (20% wt H3PO4, 0.490 g) were separately dissolved in deionized water (8 mL), and then added dropwise to the above solution, which was then magnetically stirred for 20 min. Next, the mixture was transferred into a 150-mL Teflon-lined autoclave, sealed and maintained at 140 °C for 2 h, and then cooled to room temperature naturally. The obtained product was collected by centrifugation, washed with deionized water and ethanol, and finally dried in a vacuum at 60 °C.

Materials

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BET
b nanozyme
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881FePOs420~430nmDLSFePOs measured by DLS was approximately 420∼430 nm

Kinetics

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881FePOsPODTMBRT881
881FePOsOXDTMB0.720.25mM0.850.19mM/min881

Applications

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881FePOsanti-tumor protocol