Az@MOF

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
8224 1182 Az@MOF Scanning electron microscopy (SEM) imaging indicated the extremely homogeneous morphology with a length of 200 nm and a width of 75 nm (Fig. 1a). Furthermore, transmission electron microscopy (TEM) images of Mn-MOFs in Fig. 1b directly displayed a pore size of 1.25 nm, which is in accordance with the result of N2 adsorption–desorption (1.25 nm) in Fig. S7.† The pore size of 1.25 nm permitted the encapsulation and release of AcManNAz (MW = 430).

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
6071 1182 Az@MOF eradicate over-expressed reactive oxygen species, synergistically promote the phagocytosis and clearance of Aβ with significantly enhanced activity and negligible adverse effects

References

ref title DOI material type comment
4367 1182 Glycoengineering Artificial Receptors for Microglia to Phagocytose Aβ aggregates https://doi.org/10.1039/D0SC07067J MOF n-porphyrin metal–organic frameworks (Mn-MOFs) with superoxide dismutase (SOD) and catalase (CAT) mimic activity are employed to carry N-azidoacetylmannosamine (AcManNAz) , AcManNAz@Mn-MOFs (Az@MOF)