Nanozyme Database

	ref	material	size	size err	size unit	size type	size comment	BET	b _nanozyme	b 10ⁿ	b unit	specific act	sa 10ⁿ	sa unit	comment
7407	109	IrOx	~24.05		nm	TEM	The as-prepared nanoparticles show a spherica morphology with diameter of ~24.05±0.29 nm (Figure 1b)
8454	1455	IrOx				TEM	The as-prepared nanoparticles show a spherical morphology with diameter of ~24.05±0.29 nm (Figure 1b). They were composed by the accumulation of many small granules (2.28±0.4 nm) formed at the initial heating period (Figure S2).

	ref	material	enzyme type	substrate	pH	T	k_m	k_m err	k_m 10ⁿ	k_m unit	v_max	v_max err	v_max 10ⁿ	v_max unit	k_cat	k_cat err	k_cat 10ⁿ	k_cat unit	k_cat/k_m	k_cat/k_m 10ⁿ	k_cat/k_m unit	comment
7367	1455	IrOx	POD																1455
5994	109	IrOx	POD	TMB			19.27			mM	1.79			μM/s					109			109

	ref	material	application	target	method	linear range	linear ran unit	LOD	lod unit	recovery	comment
6300	1455	IrOx	Anti-tumor
5012	109	IrOx	demonstrate for the first time that iridium oxide nanoparticles (IrOx) possess acid-activated oxidase and peroxidase-like functions and wide pH-dependent catalase-like properties. Integrating of glucose oxidase (GOD) could unlock its oxidase and peroxidase activities by gluconic acid produced by catalysis of GOD towards glucose in cancer cells, and the produced H2O2 can be converted to O2 to compensate its consumption in GOD catalysis due to the catalase-like function of the nanozyme, which result in continual consumption of glucose and self-supplied substrates for generating superoxide anion and hydroxyl radical.

	ref	title	DOI	material type	comment
3340	109	Specific “Unlocking” Nanozyme‐based Butterfly Effect for Breaking the Evolutionary Fitness of Chaotic Tumor	https://doi.org/10.1002/anie.201916142	Metal oxide	Herein, we demonstrate for the first time that iridium oxide nanoparticles (IrOx) possess acid-activated oxidase and peroxidase-like functions and wide pH-dependent catalase-like properties.
4602	1455	New concept of tumor therapy: Specific “unlocking” of a nanozyme-based butterfly effect to break the evolutionary fitness of chaotic tumors	https://doi.org/10.1002/anie.201916142	Metal oxide	iridium oxide (IrOx)