Signal-off tuned signal-on (SF-T-SN) colorimetric immunoassay for amantadine using activity-metalmodulated peroxidase-mimicking nanozyme

References

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DOI
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883Signal-off tuned signal-on (SF-T-SN) colorimetric immunoassay for amantadine using activity-metalmodulated peroxidase-mimicking nanozymehttps://doi.org/10.1016/j.snb.2020.127933Metalthe use of the activity-metal modulated peroxidasemimicking nanozyme, polyvinylpyrrolidone (PVP) capped Pt nanocubes (PVP-PtNC)

Materials

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BET
b nanozyme
b 10n
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sa 10n
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883PVP-PtNC45.3 ± 14.0nm

Kinetics

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T
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vmax 10n
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kcat
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kcat/km
kcat/km 10n
kcat/km unit
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883PVP-PtNCPODTMB + H2O2883

Applications

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linear range
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883PVP-PtNCthis “off-to-on” pathway makes the nanozyme-based colorimetric signal proportional to AMD concentrations, thereby circumventing the inherent drawbacks of limited signaling abilities and sensitivities with conventional signal-off immunoassay-based small molecule detection systems. AMDamantadine (AMD)