Stimuli-Responsive Small-on-Large Nanoradiosensitizer for Enhanced Tumor Penetration and Radiotherapy Sensitization

References

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199Stimuli-Responsive Small-on-Large Nanoradiosensitizer for Enhanced Tumor Penetration and Radiotherapy Sensitizationhttps://doi.org/10.1021/acsnano.0c03094Compositedisassembled small-on-large molybdenum disulfide/hafnium dioxide (MoS2/HfO2) dextran (M/H-D) nanoradiosensitizer.

Materials

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BET
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199HfO2 NPs10nmTEMThe size of HfO2 NPs (2–5 nm) anchored on the surface of MoS2 was smaller than the HfO2 NPs alone (10 nm), which could be attributed to the two different nucleation centers of HfO2 in the presence or absence of MoS2 NSs in the solution.
199HfO2 NPs2~5nmTEMThe size of HfO2 NPs (2–5 nm) anchored on the surface of MoS2 was smaller than the HfO2 NPs alone (10 nm), which could be attributed to the two different nucleation centers of HfO2 in the presence or absence of MoS2 NSs in the solution.
199M/H-D213.215.8nmDLSAfter the modification of dextran, dynamic light scattering (DLS) measurements showed the average hydrous dynamic diameter of 70% of the M/H-D was ∼213.2 ± 15.8 nm (Figure S2).
199MoS2100-200nmTEMa layered structure with approximately average size (the longest part) of 100–200 nm and uniform edges.

Kinetics

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Applications

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199M/H-DEnhanced Tumor Penetration and Radiotherapy Sensitization