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A nanozyme‐based artificial peroxisome ameliorates hyperuricemia and ischemic stroke

References

ref title DOI material type comment
3693 506 A nanozyme‐based artificial peroxisome ameliorates hyperuricemia and ischemic stroke https://doi.org/10.1002/adfm.202007130 Carbon FeN-carbon hollow nano-structure

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7739 506 Fe–N4 pero-nanozysome 120 nm TEM the pero-nanozysome had a spherical morphology with hollow structure, and the average diameter was about 120 nm with a shell about 4–6nm thickness 0.027 ±0.002 U/mg UOD
7738 506 Fe–N4 pero-nanozysome 120 nm TEM the pero-nanozysome had a spherical morphology with hollow structure, and the average diameter was about 120 nm with a shell about 4–6nm thickness 6.0 ±0.9 U/mg POD
7737 506 Fe–N4 pero-nanozysome 120 nm TEM the pero-nanozysome had a spherical morphology with hollow structure, and the average diameter was about 120 nm with a shell about 4–6nm thickness 1257.1 ±122.8 U/mg SOD
7736 506 Fe–N4 pero-nanozysome 120 nm TEM the pero-nanozysome had a spherical morphology with hollow structure, and the average diameter was about 120 nm with a shell about 4–6nm thickness U/mg
7735 506 Fe–N4 pero-nanozysome 120 nm TEM the pero-nanozysome had a spherical morphology with hollow structure, and the average diameter was about 120 nm with a shell about 4–6nm thickness 41.7 ± 7.9 U/mg CAT

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
6373 506 Fe–N4 pero-nanozysome （单位无法填写） CAT H2O2 7.0 RT 0.09 M 2.34 506 The KM value of pero-nanozysome was about four times lower than that of N-nanozyme (Table S3, Supporting Information),
6372 506 Fe–N4 pero-nanozysome OXD TMB 4.5 37 0.55 mM 45.27 nM/s 506 In addition, pero-nanozysome also possessed higher catalytic efficiency than that of N-nanozyme (Figure 3e and Table S6, Supporting Information).
6371 506 Fe–N4 pero-nanozysome POD TMB 4.5 37 0.18 mM 299.8 nM/s 506 pero-nanozysome exhibited higher enzymatic activity as evaluated by the values for KM and Vmax (Table S5, Supporting Information).
6370 506 Fe–N4 pero-nanozysome POD H2O2 4.5 37 175.5 mM 567.9 nM/s 506 pero-nanozysome exhibited higher enzymatic activity as evaluated by the values for KM and Vmax (Table S5, Supporting Information).
6369 506 Fe–N4 pero-nanozysome cascade reaction UA 8.0 25 16.64 μM 1.36 -3 μM/min 506 506

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5450 506 Fe–N4 pero-nanozysome Hyperuricemia and Ischemic Stroke


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