The Fe‐N‐C Nanozyme with Both Accelerated and Inhibited Biocatalytic Activities Capable of Accessing Drug–Drug Interactions

References

ref title DOI material type comment
3391 160 The Fe‐N‐C Nanozyme with Both Accelerated and Inhibited Biocatalytic Activities Capable of Accessing Drug–Drug Interactions https://doi.org/10.1002/ange.202003949 Single-atom Fe-N-C

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7453 160 Fe-N-C Thetransmission electron microscopy (TEM) images disclosed the onion-like nanoparticles of tens of nanometers with multiple graphitic shells and void cores for Fe-N-C-850

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
6046 160 Fe-N-C-850 OXD TMB RT 0.23 mM 0.133 μM/s 160 160
6045 160 Fe-N-C-400 OXD TMB RT 0.269 mM 0.338 μM/s 160 160

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5066 160 Fe-N-C It is interesting that Fe-N-C not only demonstrated the similar function of CYP3A4 in the metabolization of 1,4-DHP but also had avery high level of similarity in inhibiting interactions with other drugs