Self‐Assembled Single‐Site Nanozyme for Tumor‐Specific Amplified Cascade Enzymatic Therapy

References

ref title DOI material type comment
3688 501 Self‐Assembled Single‐Site Nanozyme for Tumor‐Specific Amplified Cascade Enzymatic Therapy https://doi.org/10.1002/anie.202008868 Composite copper hexacyanoferrate (Cu-HCF) modified with polyethylene glycol (PEG) protection layer single-site nanozymes(Cu-HCF SSNEs)

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7731 501 Cu-HCF SSNEs 128.3 4.2 nm DLS The hydrodynamic size of SSNEs was measured to be 128.3±4.2 nm by dynamic light scattering (DLS) analysis, which is larger than the TEM results due to the existence of PEG layer.
7730 501 Cu-HCF SSNEs 102.5 21.8 nm TEM Monodispersed SSNEs were obtained with a statistical size of 102.5±21.8 nm

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
6362 501 Cu-HCF SSNEs OXD GSH 0.09 0.05 mM 25.7 0.8 -3 mM/s 501 501
6361 501 Cu-HCF SSNEs OXD H2O2 71.9 8.2 mM 17.2 0.5 -3 mM/s 501 SSNEs pretreated with GSH (denoted as SSNEs-G)

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5445 501 Cu-HCF SSNEs Tumor-Specific Amplified Cascade Enzymatic Therapy