ref | title | DOI | material type | comment |
---|---|---|---|---|
838 | Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington's Like Disorder in Preclinical Model | https://doi.org/10.1002/adhm.202001736 | Metal oxide | citrate functionalized manganese-based biocompatible nanoscalematerial (C-Mn3O4 NPs) |
ref | material | size | size err | size unit | size type | size comment | BET | b nanozyme | b 10n | b unit | specific act | sa 10n | sa unit | comment |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
838 | C-Mn3O4 NPs | 6.12 | 2.24 | nm | TEM | Transmission electron micrograph (TEM) shows the C-Mn3O4 NPs to be well-dispersed uniform spheres with an average diameter of ≈6.12 ± 2.24 nm. |
ref | material | enzyme type | substrate | pH | T | km | km err | km 10n | km unit | vmax | vmax err | vmax 10n | vmax unit | kcat | kcat err | kcat 10n | kcat unit | kcat/km | kcat/km
10n | kcat/km unit | comment |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
838 | C-Mn3O4 NPs | GPx | GSH | 1.36 | 0.09 | mM | 0.064 | 0.008 | mM/min | 46.73 | 0.31 | 1/min | 838 | M-1 s-1 | For oxidation of GSH, the values were found to be kcat ≈ 46.73 ± 0.31 min−1 and kcat/KM ≈ 5717.85 ± 345.72 M s−1. | ||||||
838 | C-Mn3O4 NPs | GPx | H2O2 | 1.09 | 0.06 | mM | 0.095 | 0.011 | mM/min | 69.12 | 0.52 | 1/min | 838 | M-1 s-1 | The C-Mn3O4 nanozyme catalyzed the reduction of H2O2 with a turnover number (kcat) of ≈69.12 ± 0.52 min−1 and an apparent second-order rate constant, kcat/KM ≈ 10 530.17 ± 975.25 M s−1. |
ref | material | application | target | method | linear range | linear ran unit | LOD | lod unit | recovery | comment |
---|---|---|---|---|---|---|---|---|---|---|
838 | C-Mn3O4 NPs | cellular antioxidant enzyme cascade reverses huntington's like disorder in preclinical model |