Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington's Like Disorder in Preclinical Model

References

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838Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington's Like Disorder in Preclinical Modelhttps://doi.org/10.1002/adhm.202001736Metal oxidecitrate functionalized manganese-based biocompatible nanoscalematerial (C-Mn3O4 NPs)

Materials

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838C-Mn3O4 NPs6.122.24nmTEMTransmission electron micrograph (TEM) shows the C-Mn3O4 NPs to be well-dispersed uniform spheres with an average diameter of ≈6.12 ± 2.24 nm.

Kinetics

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838C-Mn3O4 NPsGPxGSH1.360.09mM0.0640.008mM/min46.730.311/min838M-1 s-1For oxidation of GSH, the values were found to be kcat ≈ 46.73 ± 0.31 min−1 and kcat/KM ≈ 5717.85 ± 345.72 M s−1.
838C-Mn3O4 NPsGPxH2O21.090.06mM0.0950.011mM/min69.120.521/min838M-1 s-1The C-Mn3O4 nanozyme catalyzed the reduction of H2O2 with a turnover number (kcat) of ≈69.12 ± 0.52 min−1 and an apparent second-order rate constant, kcat/KM ≈ 10 530.17 ± 975.25 M s−1.

Applications

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838C-Mn3O4 NPscellular antioxidant enzyme cascade reverses huntington's like disorder in preclinical model