Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy

References

ref title DOI material type comment
3337 106 Immunomodulation‐Enhanced Nanozyme‐Based Tumor Catalytic Therapy https://doi.org/10.1002/adma.202003563 Composite TGF-β inhibitor (TI)-loaded PEGylated iron manganese silicate nanoparticles (IMSN) (named as IMSN-PEG-TI) are constructed to trigger the therapeutic modality.

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
7405 106 IMSN-PEG-TI 100 nm TEM The typical transmission electron microscopy (TEM) and scanning electron microscopy (SEM) images indicated the as-prepared IMSN exhibited a uniform spherical morphology with an average diameter of about100 nm, and the surface of IMSN became rough (Figure 1b,c).

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
5992 106 IMSN-PEG-TI POD H2O2 49.8 -3 M 5.283 -8 M/s 106 106

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5010 106 IMSN-PEG-TI The results show that IMSN nanozyme exhibits both intrinsic peroxidase-like and catalase-like activities under acidic TME, which can decompose H2O2 into hydroxyl radicals (•OH) and oxygen (O2), respectively