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Porous selenium nanozymes targeted scavenging ROS synchronize therapy local inflammation and sepsis injury

References

ref title DOI material type comment
4250 1063 Porous selenium nanozymes targeted scavenging ROS synchronize therapy local inflammation and sepsis injury https://doi.org/10.1016/j.apmt.2020.100929 Others a novel mesoporous selenium-hyaluronic acid nanoenzyme therapeutic system (MSe-HA NPs)

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
8128 1063 MSe NPs 17.7 nm Others Then, the N2 adsorption and desorption isotherms showed that MSe NPs has obvious hysteresis loop (Fig. 1E) with an average pore size of 17.7 nm (Fig. 1F), indicating that MSe NPs were typical mesoporous nanoparticles [42,47], whereas the solid Se NPs without corresponding performance (Fig. 1G).
8127 1063 Se NPs 546.470
8126 1063 MSe NPs 150 nm TEM The transmission electron microscope (TEM) (Fig. 1A) and high-resolution TEM (HRTEM) (Fig. S1B) showed that the mesochannels distributed on the spheres throughout the MSe NPs with average size of 150 nm, which proved we have prepared the porous Se NPs. 1160.195

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
7019 1063 MSe-HA NPs GPx GSH 159.8 μM 26.81 μM/min 1063 1063
7018 1063 Se NPs GPx GSH 200.59 μM 13.51 μM/min 1063 1063
7017 1063 MSe NPs GPx GSH 157.72 μM 27.36 μM/min 1063 1063

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
5976 1063 MSe NPs synchronize therapy local inflammation and sepsis injury


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