Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions

References

ref title DOI material type comment
4340 1155 Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions https://doi.org/10.1038/s41467-020-20275-0 Multi-metal Au25, Au24Cu1 and Au24Cd1

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
8203 1155 Au25 2 nm DLS The hydrodynamic size of Au25 is determined to be 2.0 nm by dynamic light scattering (DLS), and the zeta potentials of all clusterzymes are around −35 mV, suggesting the ultrasmall size and good colloid stability (Supplementary Fig. 1).

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
7120 1155 Au24Cu1 CAT 0.35 mM/min 1155
7119 1155 Au25 CAT 0.074 mM/min 1155
7118 1155 Au24Cd1 GPx 0.10 mM/min 1155
7117 1155 Au24Cu1 GPx 0.34 mM/min 1155
7116 1155 Au25 GPx 0.47 mM/min 1155

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
6050 1155 Au25, Au24Cu1 and Au24Cd1 modulation of neuroinflammation