A cerium oxide@ metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy

References

ref title DOI material type comment
4364 1179 A cerium oxide@ metal–organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy https://doi.org/10.1039/D1CC00001B MOF A Material of Institute Lavoisie-NH2 (MIL) shell was used to protect the enzymatic activity of CeOxvia surface modification to form a core–shell MOF nanohybrid (CeOx@MIL) with abundant –NH2 groups as postsynthetic modification sites.The target moiety poly (ethylene glycol)-folate (PEG-FA) and the signal element cyanine 3 (Cy3)-labelled caspase-3 substrate peptide (Cy3-p) were assembled on the surface of CeOx@MIL via the amide reaction to obtain functionalized CeOx@MIL (CeOx@fMIL).

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
8223 1179 CeOx@fMIL 112 nm DLS After coating with MIL, the dynamic light scattering (DLS) of CeOx indicated an increase in the mean hydrodynamic diameter particle size from 17 to 112 nm.

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
6069 1179 CeOx@fMIL as a tandem catalyst for enhanced photodynamic therapy