Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma

References

ref title DOI material type comment
4395 1210 Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma https://doi.org/10.7150/thno.51912 Multi-metal we developed a catalytic patch based on redox Cr-doped CeO2 (Cr/CeO2) nanozyme for noninvasive TBI treatment

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
8241 1210 Cr/CeO2 8~12 nm TEM the transmission electron microscopy (TEM) and high-resolution TEM (HRTEM) images of Cr/CeO2 nanozyme in Figure S1 and 1G reveal that the size of nanozyme is about 8~12 nm, and interplanar spacing of the (111) plane of CeO2 is slightly reduced from 0.3123 Å to ~0.3047 Å after Cr doping.

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
7155 1210 Cr/CeO2 POD H2O2 0.867 0.073 mM 0.159 0.024 -6 M/s 1210
7154 1210 Cr/CeO2 POD TMB 0.08 0.009 mM 0.138 0.027 -6 M/s 1210

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
6094 1210 Cr/CeO2 Cr/CeO2 nanozyme can improve the survival rate of LPS induced neuron cells via decreasing excessive RONS. The in vivo experiments show the Cr/CeO2 nanozyme can promote wound healing and reduce neuroinflammation of mice following brain trauma. The catalytic patch based on nanozyme provides a noninvasive topical treatment route for TBI as well as other traumas diseases.