Self-Protecting Biomimetic Nanozyme for Selective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer’s Disease Model

References

ref title DOI material type comment
4437 1253 Self-Protecting Biomimetic Nanozyme for Selective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer’s Disease Model https://doi.org/10.1021/jacs.0c08395 Composite The CuxO@EM-K is made of CuxO nanozyme wrapped by modified 3xTg-AD mouse erythrocyte membrane with Aβ-targeting peptide KLVFF.

Materials

ref material size size err size unit size type size comment BET b nanozyme b 10n b unit specific act sa 10n sa unit comment
8268 1253 CuxO@EM-K 78.2-165.3 nm TEM The average hydrodynamic diameter of CuxO-K increased from 78.2 ± 1.5 to 165.3 ± 3.9 nm (Figure S12A) due to formation of protein coronas around CuxO-K.

Kinetics

ref material enzyme type substrate pH T km km err km 10n km unit vmax vmax err vmax 10n vmax unit kcat kcat err kcat 10n kcat unit kcat/km kcat/km 10n kcat/km unit comment
7187 1253 CuxO@EM-K 1253

Applications

ref material application target method linear range linear ran unit LOD lod unit recovery comment
6122 1253 CuxO@EM-K Selective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer’s Disease Model